Nnmultiple myeloma pathogenesis pdf

Pathophysiology and diagnosis of multiple myeloma jatin shah, md, explains that there is no clear reason for why patients develop multiple myeloma, and so theres no clear risk factor. Jci molecular pathogenesis of multiple myeloma and its. Mm is preceded by an ageprogressive premalignant condition termed. Molecular pathogenesis of multiple myeloma request pdf. Leif bergsagel 2 1 genetics branch, center for cancer. Abstract multiple myeloma mm, an incurable hematologic malignancy. Genes localized to the copy number change regions are often. Molecular pathogenesis of multiple myeloma and its premalignant precursor w. Multiple myeloma is a form of cancer that affects bone marrow, the spongy soft tissue that lies within the hollow centre of some bones. It is characterized by a multifocal proliferation of clonal, longlived plasma cells within the bone marrow bm and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and endorgan sequelae. Mm begins as monoclonal gammopathy of undetermined significance mgus, progresses to smoldering asymptomatic myeloma and finally becomes overt. In the disease state, bone healing is limited owing to increased osteoclastic and decreased osteoblastic activity, as well as an mm. First described in 1848, mm is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein m protein. Failure of apoptosis, angiogenesis and bone marrow interaction with malignant cells.

Cell of origin and genetic alterations in the pathogenesis. A unifying event in the pathogenesis of multiple myeloma is the dysregulated expression of a cyclin d gene, either directly by juxtaposition to an immunoglobulin enhancer, as a result of ectopic expression of a maf family transcription factor, or indirectly by as yet unidentified mechanisms. Learn more about the symptoms, causes, diagnosis, risk factors, and treatment of multiple myeloma. The role of bone marrow microenvironment in mediating survival, proliferation, and resistance to therapy in myeloma is well established. Multiple myeloma is an incurable disease and, little is known about the genetic and molecular mechanism governing its pathogenesis 3.

Pathogenesis and treatments cliodhna browne tsmj issue 10 2009 30 abstract multiple myeloma is a clonal b cell malignancy involving terminally differentiated plasma cells. Multiple myeloma mm is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance mgus to plasma cell leukemia. Multiple myeloma is a heamatologic malignancy caused by clonal expansion of malignant plasma cells, associated with bone disease and hypercalcaemia as its primary metabolic complication. It is characterized by a multifocal proliferation of clonal, longlived. Multiple myeloma mm is an agedependent monoclonal tumor of bm plasma cells pcs. Multiple myeloma mm is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. Multiple myeloma is the second most common type of blood cancer after leukemia. Multiple myeloma mm is the second most common blood cancer. Request pdf pathogenesis of multiple myeloma multiple myeloma mm is monoclonal tumor of antibody secreting plasma cells pc in the bone marrow bm, that is often diagnosed by the presence. It is characterized by a multifocal proliferation of clonal, long lived. The bone marrow contains stem cells that produce three types.

Lightning bolts represent genetic mutations common in. Multiple myeloma mm is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an. Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma. Small molecules with big actions in multiple myeloma pathogenesis. Multiple myeloma mm is a b cell malignancy resulting in osteolytic lesions and fractures. Multiple myeloma mm is a bcell malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow.